I hope this saves someone some time.. I certainly wasted plenty of mine until I figured it out.
I had a lot of problems with an upgrade from FC1 to FC2 on an ASUS A7V8X-X motherboard. The most serious of which was my keyboard was flaky and the mouse just didn't work, no matter what I did to it.
Long story short I tracked it down to a BIOS problem. I upgraded the BIOS and went through the BIOS settings with a fine tooth comb. The problem eventually turned out to be the mouse was set to USB Legacy. I turned that off and most of my problems went away.
My last remaining problem is that sound STILL doesn't work.
-- Greg Gulik http://www.gulik.org/greg/ greg @ gulik.org